Hits Radio, the Bauer Media station, is relauching its breakfast show with singer Fleur East and comedians Greg Burns and James Barr.
The trio will replace Gemma Atkinson, Gethin Jones and Dave Vitty on 12 July. Atkinson will take over the drivetime programme in the coming months.
The breakfast show will continue to be broadcast from Manchester nationally. Bauer said the new version has been "informed by audience insight" and will be aimed at "family-focused" 25- to 44-year-olds.
Latest Rajar figures show that the Hits Radio breakfast show had 336,000 weekly listeners, down quarter on quarter from 347,000.
Simon Kilby, chief revenue officer at Bauer, said: "The refreshed Hits Radio breakfast show is launching with a trio of really exciting talent who will be both relevant and engaging to our family-orientated audience.
"This investment in audience growth, together with our programming expertise, offers commercial partners access to a valuable audience at scale in a simple proposition."