The campaign, which launched on 8 March and is called "keep on, keeping on", was created by WCRS.
The 30-second spot tells people to keep on with whatever they’re doing because Santander’s 123 account will fit around their lives, not the other way around.
Ennis-Hill and McIlroy both make fleeting appearances in the spot, alongside gardeners, bakers and other regular people, but do not speak. The ad is only the first in a series of spots pushing the 123 account.
Keith Moor, chief marketing officer, Santander UK said: "Santander seeks to apply a simple, personal and fair approach to all that we do. A key part of our success is our award winning 123 products that provide real, everyday value for our customers, 24 hours a day.
"The idea behind our new campaign is to show how effortlessly you can be rewarded on your everyday banking, without changing the way you do things. Just switch to Santander and we’ll do the rest."
The work was created by Hayden Rodgers, Anne-Marie Burrows, Conrad Swanston and Alex Bingham. It was directed by Neil Gorringe through Moxie.