The review comes after the comic's weekly circulation plunged to below 8,000 as its target audience of children increasingly shun print in favour of digital media.
Dundee-based DC Thomson has revealed that the comic and its much-loved characters could live on in a digital format to combat the "many challenges" it faces.
A spokesman said: "We’re celebrating the fact that The Dandy has been in print for 75 years and we’ve a lot of planning to do to ensure that our brands and characters can live on in other platforms for future generations to enjoy."
The possible closure of The Dandy marks a steep decline in the fortunes of the comic, which in it heyday in the 1950s boasted a circulation of 2m.
As recently as 2005 the Dandy and sister title The Beano had a healthy weekly circulation of 138,794 following a relaunch of the Dandy in October 2004.
At the time Bernadette Casy, development manager for children’s titles at DC Thomson, said "the future continues to be bright for the Beano and Dandy".
The Dandy was launched in 1937 at a price of 2p and now retails at £1.99.
The Cartoon Museum in London will unveil an exhibition celebrating 75 years of The Dandy on 24 October and will celebrate popular characters including Desperate Dan, Beryl the Peril and Bully Beef and Chips.