The event, which showcases the latest bike and accessory brands, has been held at Earls Court for the past five years.
Organiser Upper Street Events, hopes to attract 35,000 visitors between 29 September and 2 October 2011.
"It was a difficult decision to leave Earls Court and we will be sad to leave the great teams who we’ve worked closely with over the past five years," said Upper Street Events company director Isobel Dennis.
"However, following our success with Gadget Show Live, we are excited about what the NEC can offer The Cycle Show. This move has been cycle industry driven and we believe will give the show access to a greater reach of trade and consumer audiences creating a truly national event," she added.
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