Simon Amstell, who manages to get away with some risque questions through his humour and cheeky chappie persona, had the interview terminated after she was asked if she took diet pills.
The struggling popstar, who is on the comeback trail and recently posed semi-naked for the front cover of US rock magazine Rolling Stone, failed to see the diet pill questions as a joke.
The interview, which took place in New York, did not go at all well for the presenter, according to a report in the Daily Mirror, which quoted one insider as saying: "She just didn't get him at all. Simon was interviewing her in his usual pisstake manner but when he told her he thought she was a nutter and asked if she took diet pills, the interview was cut short."
After storming out, Britney cancelled the rest of her interviews for the day and the Channel 4 production crew had its tape of the interview confiscated.
The interview came shortly after the star caused a sensation when she kissed Madonna at the MTV Video Music Awards.
According to the Mirror's source, the star was "shaking a lot" and not making much sense.
"Whether it was down to lack of sleep is anyone's guess but she was acting really strangely."
A spokesman for Britney said of her 'Popworld' interview: "It was a slight misunderstanding. Simon asked Britney if she had changed and she responded saying, 'Why, do you think I've changed?' To which he told her he thought she seemed a bit more nuts."
He added: "The interview was cut shorter than we hoped but everything's fine -- Britney was happy."
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